TYRPHOSTIN B46
TYRPHOSTIN B46
CAS: 133550-34-2
Molecular Formula: C19H18N2O3
TYRPHOSTIN B46 - Names and Identifiers
TYRPHOSTIN B46 - Physico-chemical Properties
| Molecular Formula | C19H18N2O3 |
| Molar Mass | 322.36 |
| Density | 1.273±0.06 g/cm3(Predicted) |
| Boling Point | 621.1±55.0 °C(Predicted) |
| Solubility | DMSO or ethanol: soluble |
| pKa | 8.82±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle. Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells. Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence. Cell Proliferation Assay Cell Line: NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells. Concentration: 100 μM. Incubation Time: 1 hour. Result: Inhibited Mo-MuLV proviral DNA integration. |
TYRPHOSTIN B46 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
TYRPHOSTIN B46 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.102 ml | 15.511 ml | 31.021 ml |
| 5 mM | 0.62 ml | 3.102 ml | 6.204 ml |
| 10 mM | 0.31 ml | 1.551 ml | 3.102 ml |
| 5 mM | 0.062 ml | 0.31 ml | 0.62 ml |
Last Update：2024-01-02 23:10:35
TYRPHOSTIN B46 - Reference Information
| biological activity | AG-555 (Tyrphostin B46) is a tyrosine kinase inhibitor that interacts directly with topoisomerase I, thus, DNA relaxation is prevented. It inhibits EGFR with an IC50 of 0.7 μm. |
| Target | TargetValue EGFR (Cell-free assay) 0.7 μm |
| Target | Value |
| EGFR (Cell-free assay) | 0.7 μM |
| in vitro study | AG 555 (100 μm) and the late stages (viral protein synthesis) in the virus life cycle. Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells. Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence. Cell Proliferation Assay Cell Line: NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells. Concentration: 100 μM. Incubation Time: 1 hour. Result: Inhibited Mo-MuLV proviral DNA integration. |
| Cell Line: | NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells. |
| Concentration: | 100 μM. |
| Incubation Time: | 1 hour. |
| Result: | Inhibited Mo-MuLV proviral DNA integration. |
Last Update：2024-04-09 21:54:55
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
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Product Name: Tyrphostin AG 555 Visit Supplier Webpage Request for quotationCAS: 133550-34-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: TYRPHOSTIN B46 Visit Supplier Webpage Request for quotationCAS: 133550-34-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Tel: 18301782025
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View History
TYRPHOSTIN B46
对甲基苯磺酰甲基异氰
4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-[4-(2-propen-1-yloxy)phenyl]-
2,5-Dimethoxyphenyl Isocyanate
Insulin-Like Growth Factor Binding Protein 5, Recombinant, Human (IGFBP5)
3,5-DI(TRIFLUOROMETHYL)PHENYLISOCYANATE
西替利嗪甲基酯(USP)
4-{5-{4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl}-2-nitrophenyl}morpholine
1H-Pyrrole, 2,4-dinitro-
Peramivir Impurity 29 Hydrochloride
对甲基苯磺酰甲基异氰
4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-[4-(2-propen-1-yloxy)phenyl]-
2,5-Dimethoxyphenyl Isocyanate
Insulin-Like Growth Factor Binding Protein 5, Recombinant, Human (IGFBP5)
3,5-DI(TRIFLUOROMETHYL)PHENYLISOCYANATE
西替利嗪甲基酯(USP)
4-{5-{4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl}-2-nitrophenyl}morpholine
1H-Pyrrole, 2,4-dinitro-
Peramivir Impurity 29 Hydrochloride